Partnering
Kaitlyn Christian, Santamaria won her first
WTA 125 doubles title at the
2021 Open de Saint-Malo, defeating
Hayley Carter and
Luisa Stefani in the final. She claimed her maiden
WTA 250 doubles crown at the
2022 Monterrey Open, playing with
Catherine Harrison and overcoming
Han Xinyun and
Yana Sizikova in the final. Alongside
Yana Sizikova, Santamaria won the doubles at the WTA 250
2023 Morocco Open with a win in the final against
Lidziya Marozava and
Ingrid Martins. Partnering with
Dalila Jakupović, she won another doubles title at the WTA 125
2024 Mumbai Open, defeating
Arianne Hartono and
Prarthana Thombare in the final. At the WTA 125
2024 Makarska International Championships, Santamaria and
Iryna Shymanovich overcame
Nao Hibino and
Oksana Kalashnikova in a deciding champions tiebreak to win the doubles final and take the title. Partnering
Aleksandra Krunić, Santamaria finished runner-up in the doubles at the
2025 Auckland Open, losing the final to
Jiang Xinyu and
Wu Fang-hsien. In April 2025, again alongside Krunić, she won the doubles title at the
Rouen Open, defeating top seeds
Irina Khromacheva and
Linda Nosková in the final. Teaming up with
Anastasia Dețiuc, Santamaria won the doubles title at the
2026 Ostrava Open, overcoming wildcard entrants
Lucie Havlíčková and
Dominika Šalková in the final. ==Personal life==