It was established in 1952 by the
Roman Catholic Archdiocese of Karachi. Saint Patrick's College is a co-educational institution offering courses leading to the Intermediate certificate of education and
baccalaureate degrees from the
University of Karachi. In 1972 it was nationalized by the
Government of Pakistan. The denationalization was opposed by the Sindh Professors and Lecturers Association and Muttahida Majlis-i-Amal who claimed it would result in doors being closed to students from poor- and middle-class families. The Father Stephen Raymond Scholarship Program for students was launched by the college in 2014. On January 5, 2020, the fifth scholarship ceremony was held at the College, attended by Cardinal
Joseph Coutts. ==Principals==