Vedanayakam Samuel Azariah was born in 1874 in the village of Vellalanvilai,
Thoothukudi District,
Tamil Nadu, in the far south of India to Anglican priest Thomas Vedanayagam, and his second wife Ellen. His family was previously traditionally orthodox Hindu and dedicated to the god
Shiva (hence the Tamil family name Vedanayakam possibly reflecting Shiva's three-pronged spear or one of many names of his son
Murugan). Thomas had converted to Christianity in 1839 while at a Church Missionary Society school. He named his son Samuel after the Old Testament prophet, because of the 13-year gap after the couple had a daughter. Thomas died in 1889, but Samuel was brought up by his devout mother, who sent him at age 10 to be educated at Christian missionary boarding schools including the one at
Megnanapuram run by his half-brother Ambrose, as she became the matron of the related girls' school. At the school in
Tirunelveli (called Tinnevelly during British rule), Azariah helped found a society to overcome caste differences, not a popular position with his caste but which foreshadowed later developments in his career. Samuel Vedanayakam was then sent to the provincial capital,
Chennai (then known as Madras), where the British principal of
Madras Christian College gave him the name Azariah to distinguish him from other boys. There, his classmates included K.T. Paul (1876-1931), with whom Azariah would later work. He also came into contact with American missionary
Sherwood Eddy, who also became a lifelong friend. Azariah studied mathematics like one of his elder brothers who also became a missionary, but he never received a degree; he completed his coursework in 1893 but fell ill shortly before his final mathematics exam and later chose not to retake it. Later, Azariah would criticize those who flaunted their degrees without becoming B.A. (meaning Born Again). Instead, Azariah became an evangelist with the nondenominational
Young Men's Christian Association (YMCA) at age 19. By 1895, he led YMCA spiritual meetings and directed the opening of a new branch in Madras. In 1896 he met the evangelist
John Mott who noted his enthusiasm favorably. In 1902 Azariah traveled to
Jaffna in
Sri Lanka to evangelize among the Tamils, which caused him to reevaluate the relatively prosperous Tinnevelly church's position concerning evangelization. The following year Azariah revitalized a long-dormant proposal and thus helped form the
Indian Missionary Society (IMS) (based in Tinnevelly), whereby fellow Tamil Christians could evangelize among their brethren. Azariah also served as secretary of the YMCA in south India from 1895 to 1909, and remained convinced of the importance of indigenization in the Christian mission. On Christmas Day, 1905, in Carey's library at
Serampore in
West Bengal, the interdenominational National Missionary Society was founded, with Azariah as its secretary and a mission to evangelize not only in India, but also in Afghanistan, Tibet, and Nepal. Other prominent individuals among the 17 founders included K.T. Paul, J.W.N. Hensman, Savarirayan Jesudasan and
Ernest Forrester Paton. Furthermore, in 1907, Azariah attended the World Student Christian Federation Conference in
Tokyo and the YMCA conference in
Shanghai, and remained interested in evangelizing strategies for Japan and China, as well as India. He focused on a pan-Asian global vision and converting Asians, rather than nationalists' call to free Asia from Western domination. In 1898, Azariah married Ambu Mariammal Samuel, one of the first Christian women in South India to take a college course, whom he described as "the most spiritually minded girl in Tirunelveli." Their marriage broke or reinterpreted several native religious traditions, since the bride and groom corresponded with each other before marriage, disregarded dowry customs, set a mere 40 rupee budget for the ceremony, and married on a Wednesday. The couple eventually had four sons (George, Henry, Edwin, and Ambrose) and two daughters (Grace and Mercy). ==Ministry==