In 1819 Noble gave up his profession to become the successor of Thomas F. Churchill, M.D., a minister of the Cross Street congregation, which was then worshipping in Lisle Street,
Leicester Square. He was ordained on Whitsunday, 1820. His ministry was effective, although he had a speech defect. The congregation, which had been declining, was increased by Noble to a more solid prosperity, and purchased (about 1829) the chapel in Cross Street vacated by
Edward Irving. In addition to his regular duties Noble worked as a lecturer in London and the provinces. His leadership of his denomination was not undisputed. His first controversy was with
Charles Augustus Tulk, who was excluded from the society. Noble developed a doctrine which was viewed as a heresy by many of his co-religionists: he held that
Jesus Christ was not resuscitated in the same body, but rather his body dissipated in the grave, and replaced at the resurrection by a new and divine frame. Hence arose the controversy between "resuscitationists" and "dissipationists";
John Clowes and
Robert Hindmarsh rejected Noble's view, and his major antagonist was William Mason (1790–1863). In support of his position, a "Noble Society" was formed. ==Last years==