By his first wife, Martha, daughter of Dr. Henry Bourne, an eminent physician of
Chesterfield, he had one son, Sir
Christopher Pegge, M.D. (1764 – 22 May 1822), and a daughter, Charlotte Anne, who died unmarried on 17 March 1793. He married, secondly, Goodeth Belt, aunt to Robert Belt, esq., of
Bossall,
Yorkshire. Christopher Pegge, together with Wall and Bourne was one of the three most important doctors in Oxford in the early nineteenth century. quotes the following rhyme about them, entitled
The Oxford medical trio: I would not call in any one of them all, For only "the weakest will go to the Wall"; The second, like Death, that scythe-armed mower, Will speedily make you a peg or two lower; While the third, with the fees he so silently earns, Is "the bourn whence no traveller ever returns". Another rhyme, about Sir Christopher Pegge, went: Like Circe Sir C. can prescribe a mixt cup, But mixtures Circeian beware to drink up ==Samuel Pegge's major works==