Four Spain cities were destroyed there: the second location of El Barco, which was established in 1551 by Juan Núñez del Prado; “Córdoba del Calchaquí”, which was established in 1559 by Juan Pérez de Zurita; “San Clemente de la Nueva Sevilla”, which was established in 1577 by Gonzalo de Abreu y Figueroa and “Nuestra Señora de Guadalupe”, which was established in 1630 by Felipe de Albornoz. All of them did not last long and disappeared because of the defense of the Calchaquí indigenous people, who were the local part of the Diaguita ethnic. After 1637, the Jesuits established in this place the Mission of San Carlos; although it lasted some years more, it was destroyed in 1660 during the last of Calchaquí war. Even though the mission was reestablished after being destroyed, the Calchaquí Valleys were almost deserted for many years since the majority of its population was moved a great distance to Córdoba and even to the proximities of Buenos Aires. The village was growing around the mission. San Carlos was the most important population of the valleys (at the time of independence) which had a noticeable Peninsular tendency and it constitutes itself as the center of the royalist opposition led by colonel Aramburú. In 1813, Pio Tristán's officers sacked the village and destroyed everything so as it would not fall into the power of the patriotic force hands which- after the battle of Tucumán- advanced towards Salta. In the following months, the population had been declared in [favor] of the independence struggle and because of this in those days colonel Gregorio Aráoz de Lamadrid was helped with mules and horses in 1817 when he was making an incursion into
Upper Peru. Being one of the most important villages of Salta, the relevant actions were carried out to make San Carlos the capital city of Salta but it lost with Salta by one vote. Artisans work and sell their products and they work with fabric, leather, ceramic, symbol and regional wine. There is an inn and a municipal campsite. == Church of San Carlos Borromeo - San Carlos 1801/1854 ==