The mission location was originally a native
Sobaipuri or
O'odham (Upper Pima) settlement, which Eusebio Kino visited in 1690. The mission was established in 1691, with Juan de San Martín as resident priest. By the late 1690s, the mission consisted of a church, a carpentry shop, and a blacksmith's area. Under Jesuit supervision, Pima laborers built a small chapel in 1701, using adobe bricks and basic tools. The first
Franciscan priest,
Juan Crisóstomo Gil de Bernabé, arrived in 1768 and took up residency at the mission with about fifty families. The
Apaches attacked in 1769 and killed all but two of the few Spanish soldiers guarding the mission; in 1770 and 1771 the natives continued their attacks and the
cabecera was relocated to Tumacácori. Mission Los Santos Ángeles de Guevavi was abandoned for the last time by 1776. == Missionaries ==