On June 17, 1967, the municipality of San Guillermo was created by virtue of Republic Act No. 4906, sponsored by Melanio Singson, the then-representative of
Isabela's lone district. It used to consist of 15 barangays from
Angadanan (i.e. Anonang, Colorado, Calaoagan, Dipacamo, Peredo Edcor, Guam, Nakar, Palawan, Progreso, San Francisco Norte, San Mariano Norte, San Mariano Sur, Villa Rose, Villa Sanchez, and Villa Teresita) and four from
Echague (i.e. Aringay, Dingading, San Francisco Sur and Sinalugan). Due to a noticeable increase in the rate of population migration and potential economic growth, additional barangays were created during the term of Mayor Alvaro Filart, such as barangays Burgos, Dietban, Estrella, Rizal, San Rafael and Villa Remedios. Subsequently, barangay Peredo Edcor was split into two barangays, namely: Centro 1 and Centro 2, which is now the
poblacion and the municipality's official seat. ==Geography==