Baloch began her career as a talk show anchor on Sindhi television channel
KTN. She hosted two shows,
Sanam Small Room and
Diyoo on KTN. Her acting debut was long play
Kalaq opposite
Fahad Mustafa. She then portrayed Noorulain Aneez, an innocent orphan in drama
Noorpur Ki Rani, an adaptation of
Daphne Du Maurier's
Rebecca. For her performance, she received her first ever nomination, Best Television Actress - Satellite at the
9th Lux Style Awards. Baloch paired opposite
Fawad Khan in period-drama
Dastaan. Based on
Razia Butt's novel
Bano, Baloch portrayed the eponymous character, a supporter of
Pakistan movement whose life is shattered by the
Partition of India. Taneeya Hasan of
The Express Tribune termed her performance along with Khan's performance as "a remarkable job". The performance earned her Best Drama Actress award at the
2nd Pakistan Media Awards and a nomination of Best Television Actress - Satellite at the
10th Lux Style Awards. Her first role in 2011 was in
Zindagi Dhoop Tum Ghana Saya, where she depicted a married woman who is widowed suddenly and faces the numerous challenges.
Dawn hailed her as "revelation" and opined that, "After
Daam and
Chemistry, she once again puts in a perfect performance." Baloch had her first role of 2012 in drama
Durr-e-Shehwar, as the eponymous newly-wed bride navigating the complexities of the married life. While praising her performance, Usman Ghafoor of
The News on Sunday opined that she "looks pretty and distressed as Shahwar is supposed to". The same year, Baloch played a victim of domestic abuse from a rural background in
Aik Thi Paaro. Her next role was of a victim of domestic abuse in social drama
Kankar. Farahnaz Moazzam of the
Express Tribune stated that she "depicted a battered woman’s experience beautifully". She took no acting projects for the following three years due to her commitment to hosting,
The Morning Show on
ARY News. In 2016, she returned to acting and portrayed the fighter pilot
Marium Mukhtiar in the biographical television film
Ek Thi Marium. In 2019, she starred in drama
Khaas as a victim of emotional abuse at the hands of her narcissistic husband, played by
Ali Rehman Khan. While reviewing her and Khan's performances, Buraq Shabbir of
The News International found that they has done "a commendable job" and noted their "respective roles that break away from cliched portrayals." For her performance, Baloch received a Best Television Actress nomination at the
1st Pakistan International Screen Awards. She hosted the morning show
Morning with Hum on Hum TV. In 2011, she began hosting
Samaa TV's morning show
Subh Saverey Samaa Ke Saath, a role she held for three years. She married Abdullah Farhatullah, also a Samaa TV show host. She then joined
ARY News, hosting their morning show from 2014 to 2018. Later, she rejoined Samaa TV, hosting the morning show until its conclusion in 2019. Pakistani films like
Bin Roye and
Balu Mahi and many others was also offered to Sanam Baloch. In fact, she had signed Bin Roye as well but later she cancelled the contract with
Hum TV in lieu of her morning show with
ARY News and her wedding. Baloch is one of the highest-paid actresses of Pakistan. ==Television==