Cristina Yang is introduced as a graduate from
Stanford University and a fellow
surgical intern to
Meredith Grey (
Ellen Pompeo),
Izzie Stevens (
Katherine Heigl),
Alex Karev (
Justin Chambers) and
George O'Malley (
T. R. Knight); the five of them working under
resident Miranda Bailey (
Chandra Wilson). An
atheistic competitive intern of Korean-American ancestry, she first desired to become a doctor after a childhood car accident which killed her biological father. Yang also had
dyslexia, and was raised in
Beverly Hills,
California by her mother and supportive
Jewish stepfather. She has a B.A. from
Smith College, an M.D. from Stanford University and a Ph.D. from
University of California, Berkeley, making her a "double doctor". While her emotional pragmatism, competitive perfectionism, and logical nature lead many to view her as a cutthroat "robot," Cristina hits it off with Meredith on their first day and the pair soon become best friends and each other's "person," sharing the same "dark and twisty" view of life and sense of humor. During her internship, Cristina has an on and off relationship with the chief of
cardiothoracic surgery Preston Burke (
Isaiah Washington) that leads to an accidental pregnancy. Yang schedules an abortion without telling him about the pregnancy due to Burke's behavior towards their lack of relationship status. However, Yang experiences an
ectopic pregnancy and Burke discovers the pregnancy after Yang collapses from a burst
fallopian tube while in the O.R. Burke and Yang resume their relationship in the aftermath of her miscarriage. Burke gets shot after a "shooting" at the hospital and needs surgery. After Burke is shot in the arm and develops a hand tremor, Yang helps him cover it up by forming a covert partnership wherein she performs most of his surgeries. Yang initially denies involvement during a confrontation, but then confesses everything to
Richard Webber (
James Pickens Jr.), the chief of surgery. Yang's actions jeopardize Burke's chances of becoming chief, which he views as a huge betrayal. After a short breakup, Yang breaks the silence and Burke proposes marriage, which Yang accepts after eight days of hesitation. When the wedding day comes, Yang has a moment of panic before she is about to walk down the aisle but Burke leaves her because he was not sure if she was ready to commit. Burke then disappears and is not seen again until later in the series. Yang then proceeds to go on her honeymoon to
Hawaii with Meredith to recover, returning to discover that Burke has disappeared from her life and transferred to a different hospital. Burke is replaced by
Erica Hahn (
Brooke Smith), who immediately dislikes Yang for her trend of having affairs with famous surgeons, such as Burke, going so far as refusing to let her scrub in on cardiac surgeries. Eventually,
Callie Torres (
Sara Ramirez) moves in with Yang, and she still tries to earn Hahn's approval. Hahn reveals that she dislikes Yang because she reminds her of an early version of herself and continues to cut Yang out of cardiac surgeries and neglects to teach her, before eventually quitting the hospital and leaving Seattle Grace without a head of cardio (due to a disagreement with Torres). Without a teacher, Yang begins to seriously doubt the purpose of remaining in her place at Seattle Grace when the program falls to twelfth on a list of the best teaching hospitals and Burke wins the Harper Avery award without mentioning her at all, despite her saving his career. Yang tells the Chief that her current existence in the hospital is "unbearable" and that she has turned into a ghost. Yang meets
Owen Hunt (
Kevin McKidd), an army
trauma surgeon when he patches her up from being stabbed in the stomach by a falling icicle outside the hospital. The pair are immediately attracted to each other and share a brief kiss. Owen Hunt is later honorably discharged, he is hired as Seattle Grace's chief of
trauma surgery and he and Yang begin a flirtation. Yang grows emotionally when she decides to support Meredith in her relationship with
Derek Shepherd (
Patrick Dempsey), despite her logical misgivings about their staying power, and begins to be more emotionally open towards Hunt. However, Hunt has repressed memories of his time in
Iraq and
PTSD which causes Hunt to behave erratically, and even attack and strangle her while asleep. Yang attempts to be emotionally supportive but ends their relationship as she is afraid of sleeping next to him. Cristina loses her shot at being the first resident to perform a solo surgery despite being unanimously chosen by the attending surgeons, having been disciplined from failing to report the irresponsible behavior of the new interns. Meredith and Cristina have a fight during the intern scandal, and Cristina chooses Alex to be her replacement. They eventually reconcile. When Izzie discovers her life-threatening
cancer, Yang is the one she confides in over her other friends due to Yang's ability to remain emotionally distant. Yang saves Izzie's life by coming up with a treatment plan and forcing Izzie to tell their friends of her diagnosis. Hunt begins seeing a therapist, and Yang confesses her love for him. The pair begin a tentative relationship, hampered by Hunt's therapeutic progress and his hot and cold professional behavior, wherein he frequently ignores or penalizes Yang to avoid the appearance of favoritism. Hunt hires ex-colleague from the Army,
Teddy Altman (
Kim Raver), to become the chief of cardiothoracic surgery as a "gift" for Yang, after she breaks down over having no new head of cardio. Yang is unimpressed with Altman, neither published nor famous, but her calm proficiency and belief in Yang's skills win her over. A conflict arises in the trio due to Altman and Hunt's repressed feelings for each other. Altman chooses to resign her place as temporary head of cardio because of her feelings for Hunt. Devastated by the blow to her education and the depressing potential of returning to her previous directionless state, Yang begs Altman to stay and teach her, offering Hunt to Altman in exchange. Altman intellectually understands Yang choosing her gift over a man and their relationship is repaired, but Hunt is deeply hurt that Yang traded him away. Hunt subconsciously tries to sabotage Yang's education and the two break up again after Hunt is unable to decide between the two women. After Derek was shot by Gary Clark, a grieving widower who commits mass murder at the hospital, Cristina operates on Derek at gunpoint, thus saving his life. The shooter injures Hunt as well when he chooses to return for Yang over Altman and Grey treats him as Yang saves Grey's husband. Following the attack on the hospital, Yang and Hunt impulsively decide to get married. Yang had severe PTSD and is unable to bear being alone making marriage to Hunt, who understands what she's going through, attractive. Yang spends the early days of her marriage in shock and hiding at Meredith's. Due to having severe PTSD and being unable to do her job correctly anymore, Cristina quits and begins bartending and eventually throws a housewarming party. Derek helps Cristina emotionally and she ultimately decides to go to work after helping the victim of a school shooting. Yang discovers she is pregnant with Hunt's child and decides to get an abortion. Though Hunt accompanies her to the abortion, he is extremely angry with her decision. Yang then operates on Henry Burton (
Scott Foley), Altman's husband, not knowing his identity. When the surgery fails and he dies, Yang is guilt-stricken upon learning of her patient's identity. Altman forgives Yang and forces Yang to realize that she did everything possible. Altman's mentorship of Yang is punishing at times and Altman brutally emphasizes that Yang must learn patience, compassion, and the basics over the flashy surgeries Yang prefers. Altman's tutelage is successful and Yang evolves into an aware and well-rounded surgeon because of it. Altman allows Yang to come up with a wish list of dream surgeries to fulfill before Altman resigns and moves on. Yang and Hunt distance themselves from each other as they keep fighting over the abortion, despite attending marriage counseling. Hunt has a
one-night stand with a patient's friend, leaving Yang heartbroken. She decides to move on, unsure of her future with him. As the end of the fifth year of
residency is near, the surgical residents, including Yang, prepare for their
medical boards and for the different fellowships they plan on joining. After she passes her exams, Yang reconciles with Hunt and tells him she is leaving Seattle for the
Mayo Clinic, Minnesota. Afterward, Yang, Meredith, Derek,
Mark Sloan (
Eric Dane),
Lexie Grey (
Chyler Leigh) and
Arizona Robbins (
Jessica Capshaw) are involved in an
aviation accident while on the way to
Boise, Idaho to perform surgery on conjoined twins. Lexie dies, and Mark later succumbs to his injuries after they are rescued and dies. Following their rescue, Yang, traumatized, has
brief reactive psychosis which provokes violent outbursts and makes her unresponsive. Yang leaves Seattle to become a
cardiothoracic surgical fellow and goes, as planned, to the Mayo Clinic, but has difficulties adapting to her new colleagues' way of working. While in Minnesota, Yang develops a friendship with a near-retirement cardio surgeon, Craig Thomas (
William Daniels). She mainly teases him with comments regarding his old age. She also begins an affair with the head of surgery Dr. Darren Parker (
Steven Culp) who has issues with Thomas. After Thomas dies from a heart attack, Yang returns to Seattle. Cristina is re-hired and Owen asks for a divorce once Cristina wants to reconcile. Shocked, Cristina agrees, but later finds out that the potential conflict of interest regarding the plane crash lawsuit was a key motive behind Owen's request and confronts him. Owen tells her that he 'feels responsible' and was worried as he thought she was dead. They have a sexual relationship after divorcing. The hospital is sued and found guilty of negligence. The surviving doctors, including Yang, must receive $15 million of compensation each, which leads the hospital to a near-bankruptcy as the insurers refuse to pay. Yang,
Callie Torres (
Sara Ramirez), and the other surviving doctors buy the hospital with the help of the Harper-Avery Foundation to prevent it from closing, and each become members of the new directing board. After buying the hospital, Yang realizes that she was made for the O.R. and breaks things off with Owen because he still wants kids and she still does not. After breaking up with Owen, Cristina continues to excel at surgery and becomes de facto chief of cardio. Although supportive of Meredith's choice to become a mother, Cristina points out the fact that it has hurt Meredith's career and clinical judgment. This causes a wedge in their friendship. Grey attempts to catch up professionally with a research trial, but the divide widens when Cristina's trial overshadows Grey's and steals Grey's resources. When Dr. Shane Ross, a second-year resident, stands up to Meredith for her, Cristina kisses him, and later begins sleeping with him, as well as becoming his mentor and passing on the skills learned from Altman. Cristina's project is immensely successful, and she is informed that she could be considered for the Harper Avery award from her 3-D printing of a heart conduit. Grey and Yang reconcile when Grey acknowledges that Yang is correct, she has surpassed Grey, and that Grey is jealous of Yang's professional freedom and success, while her own is hampered by her family. Cristina is nominated for the Harper Avery award and is a strong candidate, however she is passed over due to her relationship with the Harper-Avery Foundation, that co-owns Grey-Sloan Memorial Hospital. Cristina goes to speak at a hospital in Zurich, Switzerland, orchestrated by Burke who built his own hospital following his winning of the Harper Avery. He offers Cristina his job as the head of the hospital so that he can spend more time with his wife and kids. Cristina accepts the offer and interviews candidates for her replacement position at the hospital, including Maggie Pierce for the new chief of cardio. Cristina transfers her hospital shares to Alex Karev and recommends he take over her seat on the board. At the end of
Season 10, she says goodbye to her co-workers she has come to know and love including Owen, Derek and Meredith. Cristina and Meredith share special moments reminiscing about all the horrors they went through and dancing it out one last time. Cristina leaves for Zurich with surgical intern Shane Ross, who chooses to leave in order to study under her in Switzerland where she now owns a research hospital. There, Cristina thrives as the new owner. After Cristina left, the others mention her from time to time, going as far as in having a phone call with her. Her voice isn't heard. She is last seen from behind at Derek's funeral, sitting with Meredith. In
Season 16, Meredith gets text messages from Cristina saying she has given her a "gift". Meredith spends the episode looking for the gift and at the conclusion of the episode we find that the gift from Yang was the new pediatric surgeon Cormac Hayes (
Richard Flood), affectionately called McWidow. He becomes a love interest for Meredith. ==Development==