Nankoma started performing music professionally in 2013. She performed at the Bayimba Festival of the Arts, following her collaboration with Sylvester Kabombo on hip hop song, "Fumbiro". After her first single,
Season she has since recorded a number of other songs, including:
Kaddugala,
Musaiza ''Wei'ka
, Babylon
, and Mercedes'' (featured on
RNW ‘s My Song program on YouTube). Sandra Nankoma toured Uganda and performed at many festivals including the Bayimba Festival of the Arts
Milege World Music Festival organized by
Milege,
Pearl Rhythm Festival,
World Music Day celebrations. In 2014, Nankoma formed a band, performing as Sandy Soul. As Sandy Soul, Nankoma toured Africa, performing in cities including Nairobi, Arusha, Abidjan, Kigali and making a one-off appearance in Paris. In 2016, she performed at the MASA Arts Festival in Ivory Coast, as a part of Afroman Spice, a Female theatre company she co-founded. Afroman Spice campaign for social change, with a focus on feminism and women's issues. Later that year she performed at Ubumuntu Festival and at the Kigali Up Festival as Sandy Soul. In 2017 Nankoma took up a music residence in Nairobi called the Soul Train. Here she collaborated with a number of East, West and South African artists including Jojo Abot (Ghana), Blinky Bill (Kenya), Jackie Manyelope, Prisca Ojwang and DJ Kampire. Sandra Nankoma was also an award winner at Visa Pour La Creation, an awards ceremony for African and Caribbean Artists. In 2018, she released her debut studio album,
Ye'nze which was mastered and released in both Uganda and France. Kaddugala (which translates to
Melanin), released as an anthem to dark skinned girls and a strong statement against bleaching, was nominated in the 2018 AFRIMAS '
All Africa Music Awards' AFRIMA 2018. Ye'nze also won Nankoma an AFRIMA award for 'Best Female Artist in African Inspirational Music'. Nankoma began touring Ye'nze in 2018. ==Acting career==