Sandra Starke was born and raised in Namibia and came to Germany at age twelve. On the recommendation of a friend, she went to the "Sportschule Friedrich-Ludwig Jahn", the sports boarding school of the
Turbine Potsdam. From 2006 to 2010 she played in the youth teams and won the German B junior championship in 2008, 2009, and 2010. In 2010 she got promoted to the professional squad, but she was mainly used for the second team in the
2. Frauen-Bundesliga North. Her first-team debut came on 23 November 2012. In the summer of 2013, Starke signed a contract with
SC Freiburg. On 14 September 2013 (second matchday) she scored her first
Bundesliga goal in the 1–2 defeat in the away game against
Bayern Munich with the goal in the 51st minute. In 2017–18 season, Starke was injured but was able to play again in the 2018–19 season and extended her contract with SC Freiburg in February 2019. In February 2021, Starke signed a three-year contract with
VfL Wolfsburg until mid-2024. In April 2023, she joined
Chicago Red Stars on loan until 30 June 2023. In July 2023, Starke signed a contract with
RB Leipzig until summer 2025. == International career ==