In 2021 it was confirmed that Ryan has agreed terms to turn professional with
Matchroom Sport. She made her pro-debut on 31 July 2021 defeating
Kirstie Bavington on points in a six-round contest held at Matchroom HQ Garden in Brentwood, England.
Ryan vs Pier Houle On April 22, 2023 at Cardiff International Arena in Cardiff, Wales, Ryan defeated Marie Pier Houle by unanimous decision and earned the vacant WBO welterweight title.
Ryan vs McCaskill On September 23, 2023 at Caribe Royale in Orlando, Florida, Ryan faced
Jessica McCaskill in the welterweight championship unification. The fight ended in a split draw.
Ryan vs Harper On 23 March 2024 in Sheffield, England, Ryan defeated
Terri Harper via fourth-round retirement and retained her WBO welterweight title.
Ryan vs Mayer Ryan was scheduled to defend her WBO welterweight title against
Mikaela Mayer in New York on 27 September 2024. She lost the fight by majority decision. On the day of the fight, while leaving to the event, she was hit by a tin of paint at her hotel. Two days after the fight Ryan demanded an immediate rematch in light of the paint incident and alleged threats against her and her support team.
Ryan vs. Mayer 2 Ryan faced Mikaela Mayer in a rematch for the WBO welterweight title at Fontainebleau in Las Vegas on 29 March 2025. She lost by unanimous decision.
Ryan vs. Grierson Ryan got back to winning ways in her next fight, defeating the previously unbeaten Jade Grierson by unanimous decision at Rainton Meadows Arena in
Houghton-le-Spring on 6 September 2025.
Ryan vs. Zamora Ryan became a two-weight world champion when she defeated Karla Ramos Zamora via majority decision to win the vacant
WBC female
light-welterweight title at Nottingham Arena on 21 February 2026. The judges' scorecards were 97–93, 97–93 and 95–95. ==Professional boxing record==