Santa Juana began her acting career in 2016. In 2022, she portrayed Cotton Allen in the science fiction horror film
The Friendship Game. She has appeared in
The Flash. In addition to her screen work, Santa Juana has a background in musical theatre. She joined the Canadian production of
Dear Evan Hansen in 2019, understudying the roles of Zoe Murphy and Alana Beck. She later joined the Broadway company, continuing in these roles. In March 2024, it was announced that Santa Juana would star as Stefani in
Final Destination Bloodlines, the sixth installment of the
Final Destination franchise. The film is directed by
Zach Lipovsky and
Adam B. Stein, and was released in May 2025. ==Filmography==