Wildlife is abundant on the island, but mainly in the surrounding waters.
Mammals The grey long-eared bat (
Plecotus austriacus) is indigenous to Cape Verde, but other than a vagrant trip, there is no evidence of habitat. There is evidence that the House Mouse (
Mus musculus) is on the island. Feral cats (Felis catus) were a major concern before being eradicated in 2020 (Medina et al., 2021).
Reptiles Several species of reptiles make their home on Santa Luzia, or use it as a breeding ground. Stanger's skink (
Chioninia stangeri), the Raso wall gecko (
Tarentola raziana), and Bouvier's leaf-toed gecko (
Hemidactylus bouvieri), as well as the endangered
Hawksbill sea turtles have been observed on the island.
Loggerhead sea turtles The nesting area with sandy beaches on the southern end of the island is considered a biodiversity hotspot. The
Loggerhead sea turtle nests on the island. The archipelago is the second-largest nesting area in the Atlantic and hosts the world's third-largest population overall. The organization Sea Sheppard has helped clean up marine debris such as discarded fishing gear.
Birds There is evidence that a colony of Cape Verde Shearwater (
Calonectris edwardsii) was historically on the island, but became extirpated with the introduction of invasive species, such as the feral cat. The same appears to be evident with the
Boyd's shearwater (
Puffinus boydi). When the cats were eradicated, the species began returning to the island. There is hope they will recolonize. The extirpated Raso Lark (
Alaudala rufescens) was reintroduced between 2018 and 2020 from Raso to Santa Luzia. Other birds with historical evidence of nesting on the island, since extirpated, are the
White-faced storm petrel (
Pelagodroma marina eadesorum). In 1912, the
Puffinus boydi was considered a subspecies of the
Puffinus lherminieri boydi. The specimen was obtained from Cape Verde. From the mid-to-late 20th century, the species was considered a subspecies of either the Little Shearwater (
Puffinus assimilis) or Audubon's Shearwater (
Puffinus lherminieri). In 2004, evidence showed a reclassification was in order. In 2022, further genetic analysis confirmed that
Puffinus boydi,
Puffinus baroli and
Puffinus lherminieri, should be treated as separate species. In 2024 the
American Ornithological Society (AOS) recognized the separate species
Puffinus boydi. The
Puffinus baroli (Puffinus boydi was considered the same species). The
Cape Verde Storm Petrel (
Hydrobates jabejabe) has two different groups that breed at different times, referred to as
temporal Isolation. The African stonechat (
Saxicola torquatus) has had unconfirmed sightings, but the Canary Island Stonechat (
Saxicola dacotiae) nests on the island. The non-native Black-headed Weaver (
Ploceus melanocephalus) was likely introduced. Sightings of the Cabo Verde Warbler (
Ploceus melanocephalus), endemic to
Santiago,
Fogo,
São Nicolau, and
Brava, are likely just vagrant. The
Cape Verde Swift (
Apus alexandri) travels between the islands, but there is no evidence of nesting on Santa Luzia. The non-breeding range of the
Northern Gannet (Morus bassanus) extends as far as the Cape Verde islands, including Santa Luzia. The
Red-footed Booby (
Sula sula) has been confirmed nesting on Raso, so sightings around Santa Luzia would be expected. The non-breeding range of the
Northern Gannet (
Morus bassanus) extends as far as the Cape Verde islands, including Santa Luzia. The
Lesser Cape Verde Kestrel (
Falco neglectus or
F. t. neglectus), a northern island subspecies of the
Common Kestrel (
Falco tinnunculus), is found on the island. In contrast, the Alexander's Kestrel (
Falco alexandri) is found on the southern islands. ==Uninhabited==