The club was founded in 1961 and have never been league champions. They were runner-up twice, in 2001–02 and in the 2012 Verano championship. They reached the top tier after winning promotion in 1999 after beating
Municipal Liberia in a May 1999 play-off final marred by violence off the pitch.
2026 Licensing Disqualification In December 2025, the Costa Rican Football Federation (FCRF) Licensing Committee announced that Santos de Guápiles, alongside
AD Guanacasteca, did not meet the necessary administrative and financial criteria to maintain their professional license for the 2026 cycle. Consequently, the club was barred from participating in the Clausura 2026 tournament, and their scheduled matches were removed from the official UNAFUT calendar. The club management has since announced plans to restructure their administrative finances to regain their status in future seasons. ==Stadium==