Ishioka debuted with a unanimous decision defeat against Kyoko Takabayashi at
Smackgirl - F 2007: The Next Cinderella Tournament 2007 First Stage on . On , Ishioka participated at
Smackgirl 2007: The Dance of the Taisho Romance in the Next Cinderella Tournament 2007 lightweight first round, where she defeated Yoko Oyama by unanimous decision. In the next round of the tournament, at
Smackgirl - F 2007: The Next Cinderella Tournament 2007 2nd Stage on ,
Mei Yamaguchi defeated Ishioka with a
kneebar. Ishioka rebounded back with three consecutive victories. The first one was against Masako Yoshida, whom Ishioka defeated by unanimous decision on at ''Smackgirl 2007: Queens' Hottest Summer
. She next defeated Miyuki Ariga, also by unanimous decision, in a match with special rules on during Kingdom of Grapple Live 2007
. Her third consecutive victory came when she defeated American fighter Thricia Poovey by armbar submission at Smackgirl 7th Anniversary: Starting Over'' on . Her
winning streak came to an end on at the hands of
South Korean kickboxer
Seo Hee Ham, who defeated Ishioka by unanimous decision in the
Smackgirl World ReMix Tournament 2008 Opening Round, during the first round of the lightweight tournament. Ishioka earned another victory by armbar submission against Harumi on at ''Kingdom of Grapple mini Live in Summerfest!! '08''. On , Ishioka made her debut with MMA promotion Jewels at
Jewels 1st Ring, where she defeated
Mika Nagano by unanimous decision in the main event. Ishioka got her first
TKO victory against Hanako Kobayashi at
Jewels 2nd Ring on . Ishioka then challenged the world's number one ranked female fighter
Megumi Fujii. On , Fujii submitted Ishioka by armbar at
Jewels 4th Ring. On at
Jewels 6th Ring, Ishioka defeated Sally Krumdiack with a controversial finish in which Ishioka had Krumdiack in a weak armbar and the referee asked Krumdiack if she was okay. Krumdiack responded that she was, but the referee mistook the answer and incorrectly stopped the fight. Ringside officials recognized the mistake and it was expected that the fight would be ruled a no contest, but the result remained as a victory for Ishioka. Ishioka got another victory at
Jewels 8th Ring when she defeated
pro-wrestler Mai Ichii by submission (armbar) on . In an
upset on in the opening round of the 2010 Jewels Lightweight Queen Tournament, Ishioka was defeated by unanimous decision in her bout against
Sakura Nomura, eliminating the favorite Ishioka from the tournament. Ishioka and Celine Haga fought on at
Jewels 10th Ring, with Ishioka winning a close but unanimous decision. Ishioka faced Yuko "Amiba" Oya in a Jewels Lightweight Queen Tournament reserve match at
Jewels 11th Ring on . She defeated Oya by submission due to an armbar in the first round. Ishioka rematched
Seo Hee Ham on at
DEEP: 52 Impact in
Tokyo, Japan. She was defeated for the second time by unanimous decision. Ishioka next faced
Yuka Tsuji in a
Jewels vs. Valkyrie bout at
Jewels 15th Ring on in
Tokyo, Japan. She was defeated by unanimous decision. Ishioka faced "Windy" Tomomi Sunaba in Sunaba's retirement bout at
Pancrase Progress Tour 3 on . She defeated Sunaba by armbar submission in the second round. After giving birth, Ishioka was scheduled to return to MMA on February 16, 2014, but her match had to be canceled when her opponent, Mika Nagano, announced her pregnancy. ==Shoot boxing career==