Nyanti held senior positions in the
Liberian Ministry of Health from 1999 to 2003, including as Director of the National AIDS Control Program. From 2005 to 2009, Nyanti worked for the UN in Nepal, before becoming UNICEF
HIV/AIDS advisor to the representatives in
Namibia and
Kenya in 2009. She was head of the UNICEF office in
Lagos from 2015 to 2015. and in
Yemen from 2019 to 2020. In January 2021, she was appointed Resident Coordinator for the UN in
Nepal. Nyanti was a key figure in the response to
Nigeria's
Ebola Virus Disease outbreak and has been a leader in the international response to the
COVID-19 pandemic. Since 2019, she has been the highest ranking Liberian in the UN. In December 2021, UN Secretary-General
António Guterres appointed Nyanti Deputy Special Representative, Resident Coordinator and Humanitarian Coordinator in
South Sudan (UNMISS) and Resident Coordinator in South Sudan, succeeding
Alain Noudéhou of
Benin. The role is an
Assistant Secretary General. Nyanti will be leading the UN's efforts in recovery and stabilization in the world's newest country. She was appointed the Minister of Foreign Affairs and Dean of the Cabinet in February 2024. ==Community service and activism==