In September 2018, Calle joined the cast of the
CBS soap opera
The Young and the Restless as chef Lola Rosales. She appeared in over 270 episodes and was nominated for
Daytime Emmy Award for Outstanding Younger Performer in a Drama Series in 2020 for her performance. In her feature film debut, Calle portrayed
Kara Zor-El / Supergirl in the superhero film
The Flash, set in the
DC Extended Universe (DCEU). She was the first
Latina actress to play the role. Released in June 2023,
The Flash received mixed reviews, but Calle received praise for her performance as Supergirl. The combined factors of the film's poor financial performance (largely attributed to lead actor
Ezra Miller's legal troubles),
Warner Bros. replacing the leadership of
DC Studios, and the impending
reboot of the DCEU in the form of the
DC Universe (DCU) meant her intended multi-project presence never came to be, and the role of Supergirl was ultimately recast with
Milly Alcock for the next project featuring the character, the DCU film
Supergirl (2026), in addition to an uncredited cameo in the preceding film
Superman (2025). In 2026, she appeared in the
Netflix film
The Rip. ==Personal life==