Clinically, three distinct patterns of palmoplantar keratoderma may be identified: diffuse, focal, and punctate. "Hereditary painful callosity syndrome", • Type 2:
Spiny keratoderma (also known as "Porokeratosis punctata palmaris et plantaris", "Punctate keratoderma", and "Punctate porokeratosis of the palms and soles") is an autosomal dominant
keratoderma of late onset that develops in patients aged 12 to 50, characterized by multiple tiny keratotic plugs, resembling the spines on a music box, involving the entire palmoplantar surfaces.
Ungrouped •
Palmoplantar keratoderma and spastic paraplegia (also known as "Charcot–Marie–Tooth disease with palmoplantar keratoderma and nail dystrophy"
keratoderma (a skin condition involving horn-like growths) with symmetric severe involvement of the whole palmoplantar surface in a glove-and-stocking distribution. It was characterized by
Virginia Sybert in 1988. An autosomal recessive form which is known as
Mal de Meleda has been described. This is associated with mutations in the Secreted Ly-6/uPAR-related protein 1 (
SLURP1) gene. •
Striate palmoplantar keratoderma (also known as "Acral keratoderma", It was characterized in 1968. •
Vohwinkel syndrome (also known as "Keratoderma hereditaria mutilans", It was characterized in 1929. •
Olmsted syndrome (also known as "Mutilating palmoplantar keratoderma with periorificial keratotic plaques", "Mutilating palmoplantar keratoderma with periorificial plaques" Treatment with retinoids has been described. It has been associated with mutations in TRPV3. •
Aquagenic keratoderma, also known as
acquired aquagenic palmoplantar keratoderma, The association with cystic fibrosis suggests an increased salt content in the skin. == Genetics ==