Main trio •
Luke Watson (voiced by
Tyger Drew-Honey), an adventurous teenage boy, who has just discovered himself to be an unstable werewolf whenever he gets angry. •
Resus Negative (voiced by
Rasmus Hardiker), a sarcastic yet funny, "rockstar vampire", who does not have fangs, cannot change into a bat, and drinks tomato juice instead of blood. •
Cleo Farr (voiced by
Tala Gouveia), a 4,000-year-old mummy, who befriends Luke and Resus, despite knowing that they are going to grow older without her.
Other residents •
Luella Everwell (voiced by
Claire Skinner), Eefa's niece and Resus' admirer. •
Doug (voiced by
Rasmus Hardiker), an undead teenager who talks like a surfer. •
Six (voiced by
Claire Skinner), a monster stitched together by Dr F who does not know much about anything. •
Dig, a reanimated dog whose lower torso is all bone. •
Lulu, Resus' large pet leech. •
Sue Watson (voiced by
Claire Skinner), Luke's mother, who tries her best to keep her family in check. •
Mike Watson (voiced by
Jim Howick), Luke's father, an overly sensitive man who has yet to get used to life on Scream Street. •
Bella Negative (voiced by
Debra Stephenson), Resus' mother. •
Alston Negative (voiced by
John Thomson), Resus' father. •
Niles Farr (voiced by
John Thomson), Cleo's embarrassing father. •
Eefa Everwell (voiced by
Debra Stephenson), the local witch and Luella's aunt. •
Dr Skully (voiced by
John Thomson), the skeletal teacher of Scream Street. •
Dr F (voiced by
Debra Stephenson), a wicked mad scientist who is Six's mother (who she reminds as her "creator"). •
Mayor Sir Otto Sneer (voiced by
John Thomson), the sniveling and conniving mayor of Scream Street. •
Dixon (voiced by
John Thomson), Otto's shapeshifting apprentice and nephew. •
Noname, Otto's faceless bodyguard. •
President McDread (voiced by
John Thomson), the leader of the monster community. ==Episodes==