Secoisolariciresinol diglucoside slows the growth of human breast cancer in mice. Secoisolariciresinol diglucoside may be manipulated by different CYP enzymes in Eukaryotes. Due to its inherent size of 687Da, it will not pass the
Blood–Brain Barrier (which is somewhat limited to molecules smaller than
500Da). For example, in one Histology group of adult patients with malignant
glioma (Grade IV), consuming Secoisolariciresinol, resulted in 'poorer' survival outcomes, while the Grade III patients resulted in more positive outcomes (SDG with
vitamin E). In rabbits, SDG reduced hypercholesterolemic atherosclerosis and this effect was associated with a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve. SDG has been shown to counter
oxidative stress in human colonic epithelial tissue and protect against mtDNA damage
in vitro, by H2O2 exposure, in a dose-dependent manner, and counters (in-vitro) oxidative stress on heart cells caused by Iron overload. == References ==