Breast Cancer SCTR neither uniformly upregulated or downregulated in tumors, hence, it has the potential to promote or suppress tumor proliferation. In a study investigating methylation of the SCTR genes in breast cancer tissue, hypermethylation and downregulation were observed; pathway analysis in MCF-10A cells determined these most likely effect the G2/M stage checkpoint. Moreover, because of the high frequency of hypermethylation at
CpG islands in colorectal cancer, SCTR hypermethylation is an effective diagnostic marker that has achieved high diagnostic performance; colorectal cancer and precursor legions were able to be distinguished using SCTR methylation as a diagnostic tool. Additionally, SCTR genes were found to be hypermethylated in cell-free DNA samples of colorectal cancer patients, but not in cells from healthy patients. == References ==