Adverse effect incidence) •
sinus tachycardia • Orthostatic hypotension •
Hypotension • Swollen tongue •
Dysphagia (difficulty swallowing) •
Glossodynia • Oral
paraesthesia Rare (0.01–0.1% incidence) adverse effects include: •
Neuroleptic malignant syndrome (Combination of
fever, muscle stiffness,
faster breathing,
sweating, reduced consciousness, and sudden change in
blood pressure and
heart rate) •
Tardive dyskinesia • Speech disturbance •
Rhabdomyolysis •
Angioedema • Blood dyscrasias such as
agranulocytosis,
leukopenia and
neutropenia • Accommodation disorder •
Pulmonary embolism •
Gynaecomastia •
Galactorrhoea Unknown incidence adverse effects • Allergic reaction • Restless legs syndrome • Oral mucosal lesions (ulcerations, blistering and inflammation) • Salivary hypersecretion •
Hyperprolactinaemia Asenapine seems to have a relatively low weight gain liability for an
atypical antipsychotic (which are notorious for their metabolic side effects) and a 2013 meta-analysis found
significantly less weight gain (SMD [standard mean difference in weight gained in those on placebo vs. active drug]: 0.23;
95% CI: 0.07-0.39) than,
paliperidone (SMD: 0.38; 95% CI: 0.27-0.48),
risperidone (SMD: 0.42; 95% CI: 0.33-0.50),
quetiapine (SMD: 0.43; 95% CI: 0.34-0.53),
sertindole (SMD: 0.53; 95% CI: 0.38-0.68),
chlorpromazine (SMD: 0.55; 95% CI: 0.34-0.76),
iloperidone (SMD: 0.62; 95% CI: 0.49-0.74),
clozapine (SMD: 0.65; 95% CI: 0.31-0.99),
zotepine (SMD: 0.71; 95% CI: 0.47-0.96) and
olanzapine (SMD: 0.74; 95% CI: 0.67-0.81) and
approximately (that is, no statistically significant difference at the
p=0.05 level) as much as weight gain as
aripiprazole (SMD: 0.17; 95% CI: 0.05-0.28),
lurasidone (SMD: 0.10; 95% CI: –0.02-0.21),
amisulpride (SMD: 0.20; 95% CI: 0.05-0.35),
haloperidol (SMD: 0.09; 95% CI: 0.00-0.17) and
ziprasidone (SMD: 0.10; 95% CI: –0.02-0.22). The same meta-analysis suggested that asenapine had a relatively high risk of extrapyramidal symptoms compared to other atypical antipsychotics but a lower risk than first-generation or
typical antipsychotics. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. It may also result in recurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped. ==Pharmacology==