Between 1992 and 2007, Segenet worked at the International Center for Tropical Agriculture (CIAT),
Colombia, first as a Senior Scientist, and later Leader of Crop and
Agroecosystem Health Management. Her research focused on elucidation of molecular determinants of host-pathogen interactions, development of novel plant disease control strategies including
genetic engineering,
biopesticides, pathogen
population genetics and
dynamics,
endophytic microbes and their role in plant development. In August 2007, Segenet decided to return to Africa, determined to contribute her experience in applying cutting-edge science to developmental issues, towards resolving the continent's problem. She accepted a position as the Director of the Biosciences eastern and central Africa (BecA) Hub. Under her leadership, the BecA initiative was transformed from a contentious idea into a driving force that is changing the face of African biosciences. BecA's research capacity, staff, facilities, funding, partners and training programs have expanded at an ever accelerating pace. She has assembled and inspired a scientific and technical team bound by a common passion for using science to enhance Africa's biosciences development. In 2013, Kelemu joined the
Alliance for a Green Revolution in Africa (AGRA) as Vice President for Programs for about a year. In November 2013, Segenet became the Director General of the
International Centre of Insect Physiology and Ecology In January 2018, Segenet was singled out by
philanthropist Bill Gates as one of five "heroes [whose] lives inspire me". ==Awards and recognitions==