Selena Lee entered the 2003
Miss Hong Kong Pageant as an overseas contestant, winning Miss Photogenic and Miss Talent. She subsequently signed with the broadcasting giant
TVB and made her acting debut in the drama
The Last Breakthrough (). In 2014, Lee portrayed Jessica Tan in the Singaporean sitcom
Spouse for House. She won the credit award for best actress in comedy in Asian Television Award. In 2017, Lee won the Best Actress awards at the European Cinematography Awards and Los Angeles Film Awards with her role in the American short film
Once More. In 2018, Lee participated in Canadian television crime drama
Blood and Water () for which she was nominated for
Best Supporting Actress at the
7th Canadian Screen Awards. In April 2019, Lee announced that she would not be renewing her contract with TVB, with intentions to pursue opportunities internationally. It was announced in May 2019 that she would be managed by American talent agency Authentic for work in North America. In September 2019, Lee portrayed the 2010s flight attendant Alex Cheung and the 1960s hostess Coco Yeung in the TVB supernatural drama ''
Barrack O'Karma (), for which she earned critical acclaim and became a strong contender for Best Actress. At the 2019 TVB Anniversary Awards, she won the Most Popular Onscreen Partnership award with her Barrack O'Karma'' co-actor
Joel Chan. Nominated for the fourth time for
Most Popular Female Character, Lee won the award alongside
Miriam Yeung for her dual role as Alex and Coco. She was placed among the top 5 nominees for Best Actress as well. Lee's last drama at TVB,
Forensic Heroes IV (), aired in February 2020. She released her first single, Second Love, with her
Forensic Heroes IV co-actor Gabriel Harrison and won music awards for the single. Lee signed an artiste contract with
Shaw Brothers Pictures for work in Hong Kong and South-Eastern Asia as well. In August 2020, she returned to TVB to film the sequel ''
Barrack O'Karma 1968'' (). The drama was aired in April 2022. She is the only one who entered top 5 for both
TVB Anniversary Awards 2022 best actress and most favorite best actress in Malaysia category. Both drama series entered the finalist of best actress in a leading role in
Asian Television Awards and People's Choice Television Award in 2020 and 2022 respectively. She released her first album in September 2022 and completed the filming of the remaking international film -
Tape. In 2023, She filmed The Queen of News and entered top 5 for both
TVB Anniversary Awards 2023 best actress and most favorite best actress in Malaysia and Greater Bay Area category. She has also been nominated for the People's Choice Television Award in best actress category. == Personal life ==