Semiz Ali Pasha was an Ottoman Bosnian statesman from the Sanjak of Bosnia who served as Grand Vizier of the Ottoman Empire from 1561 to 1565. He was the beylerbey (governor) of Egypt Eyalet from 1549 to 1553. Semiz Ali Pasha was born in Prača in Bosnia, and replaced Rüstem Pasha as Grand Vizier. After palace schooling, he discharged high-level functions along the Ottoman Empire. His epithet "Semiz" means "fat" in Turkish.