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SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene. SGTA orthologs have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif. STGA was discovered just 15 years ago.

Function
The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1. The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. Overview of main functions: • hormone signaling • viral assembly and release • cell cycle and apoptosis • intracellular compartmentalization • neuronal synaptic transmission • post-translational transport and modification of proteins. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling. The protein also mediates targets to the endoplasmic reticulum == Interactions ==
Interactions
SGTA has been shown to interact with Growth hormone receptor. Interacting Proteins for the SGTA Gene: • HSPA4BAG6UBL4AHSPA8GET4 == Associated Diseases ==
Associated Diseases
Source: • Prostate, ovary, liver, and esophagus cancer • Hormone-related polycystic ovary syndrome • Amyloid-related Alzheimer's • Prion Diseases == References ==
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