Beginning west of
Dove Creek, the highway runs north, then swings east to drop into a canyon and cross the
Dolores River at
Slick Rock. SH 141 follows the Dolores for a short while, then continues east through Gypsum Gap, then north through Broad Canyon. At a junction with
SH 145 the highway turns west through
Naturita, then northwest following the
San Miguel River to the Dolores River. It continues a winding path northwest along the Dolores to
Gateway. There it turns northeast, running through the
Unaweep Canyon to the
Gunnison River valley where it joins
US 50 at
Whitewater. The highway heads northwest alongside the Gunnison River, splitting off from US 50 as it nears
Grand Junction. It heads north across the
Colorado River and ends at a junction with
I-70 Bus. east of Grand Junction. SH 141 between Naturita and Whitewater is part of the Colorado designated
Unaweep Tabeguache Scenic Byway. overlook on SH 141 ==Major intersections==