CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon
tyrosine phosphorylation, with
SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances
tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM] == Interactions ==