Shafrir departed a history Ph.D. program to begin her career in journalism at
Philadelphia Weekly, then joining the staff of Gawker in its early years. She next worked for
Rolling Stone before joining Buzzfeed in 2012 as an editor and culture writer. Shafrir founded the
Postcards From Yo Momma website with
Jessica Grose, in 2008,where they posted reader-contributed electronic messages (texts, instant messages, and emails) from their mothers. She and Grose produced a book based on the site, titled
Love, Mom: Poignant, Goofy, Brilliant Messages from Home, which was published by
Hyperion in March 2009. Shafrir has co-hosted the podcast
Forever35, with Kate Spencer, since 2018. She is also the host of ''Matt and Doree's Eggcellent Adventure'', alongside husband
Matt Mira, focused on the couple's experience with infertility and having a child via
IVF.
STARTUP Shafrir's first novel,
STARTUP, was published by
Little, Brown on April 25, 2017. In
Rolling Stone, Helen Holmes notes Shafrir is a "a seasoned veteran in the world people still refer to as 'new media'" and says Shafrir's extensive experience in the world she describes "helps give
Startup its legs. Her measured eye and wealth of understanding is clear in the rendering of characters like Isabel, an assistant who casually leaves her phone on a coffee table when she goes to the bathroom because the notion of someone snatching it is unthinkable, and Victor, an out-of-work boyfriend convinced he's smarter and more important than his employed partner." ==Personal life==