He joined the African National Congress as a student in Fort Hare university and was instrumental in formation of ANC Youth League and became a chartered member. He return to Lesotho continue with politics and founded the Basutoland Congress Party (renamed
Basotho Congress Party after independence in 1966) in 1952 and led the party (served as its first party president) until 1997 when he resigned and formed a new political party,
Lesotho Congress for Democracy (LCD). He fought colonial rule in Lesotho and demanded greater self-rule. He also founded the influential
Mohlabani (The Warrior) and
Makatolle political newspapers. His outspoken political views caused him to be dismissed from his teaching position at Basutoland High School in 1954. His party Basutoland Congress Party won many seats during the first elections held in Lesotho in 1960. In the 1965 elections, Basutoland Congress Party came second to Basotho National Party of Leabua Jonathan. Following the 1965 elections, he formed an unsuccessful alliance with King
Moshoeshoe II to block Lesotho's independence unless another general election was held and paramount chiefs were given greater authority. The alliance ended when Moshoeshoe II gathering was suppressed by the government at
Thaba Bosiu in December 1966. In 1970 Basotho Congress Party won the elections and the Prime minister Leabua Jonathan refused to relinquish power, suspended the constitution and declared state of emergency. He seized power by force and many were imprisoned without trial for over a year. It was clear Leabua was an anti-democrat and he ruled through the barrel of the gun. In 1974, Basotho Congress Party tried unsuccessfully size power by attacking police stations and following that many were arrested, killed and reign of terror by Chief Leabua continued. Ntsu Mokhehle fled Lesotho and went into exile and resided in Botswana, Zambia and South Africa. During his exile, he presided over the establishment of
Lesotho Liberation Army and worked covertly with South African security forces in destabilizing Lesotho. Mokhehle was awarded honorary doctorates by Fort Hare University in 1996 and
National University of Lesotho in 1990. The dictator
Leabua Jonathan was overthrown by the Military, which facilitated the return of him along with others in February 1989. Basotho Congress Party of Ntsu Mokhehle won the 1993 election by landslide which deemed fair by international observers and he ruled until 1998. He led Basotho Congress Party until 1997 when he resigned and formed a new political party,
Lesotho Congress for Democracy (LCD). He did not attend an LCD conference in late January 1998 due to poor health and did not seek to be re-elected as party leader, but the party re-elected him anyway. After Mokhehle insisted he could not lead the party any longer, a new conference was held and Deputy Prime Minister
Pakalitha Mosisili was elected as party leader on 21 February. The LCD won the
parliamentary election that followed, and Mosisili replaced Mokhehle as Prime Minister. ==Death==