European Tour Lowry elected to turn professional the week after his Irish Open triumph, meaning that he would miss out on the opportunity to play in the
Walker Cup in September 2009. He made his professional début on 28 May at the
European Open, where he shot 78 in the first round to end the opening day almost at the back of the field, and went on to miss the cut following a second round 73. Lowry missed the first three cuts of his professional career, but had his first payday on 5 July, when he finished 50th at the
Open de France Alstom. He had his best professional result in 2009 in November, when he finished 3rd in the
Dunlop Phoenix Tournament in Japan. In January
2010, Lowry finished in fourth place in the
Abu Dhabi Golf Championship, moving him into the top-100 of the
Official World Golf Ranking. In June 2010, Lowry qualified for his first
major championship, the
Open Championship at
St Andrews. During the qualification, Lowry equalled
Nick Faldo's course record at
Sunningdale when he posted a 62. Lowry went on to make the cut at St Andrews and eventually finished in a tie for 37th place. Lowry won for the first time as a professional in
2012, at the
Portugal Masters in October. He shot a 67 to tie for the lead with the Englishman
Ross Fisher, who made bogey on the final hole after missing a four-foot putt. The victory lifted Lowry back into the Official World Golf Ranking top 100 and made him eligible to compete in the
WGC-HSBC Champions. In
2014, Lowry was runner-up at the
BMW PGA Championship in May and later tied for ninth at the
Open Championship at
Royal Liverpool (Hoylake), his best finish at a major. In August
2015, Lowry won the
WGC-Bridgestone Invitational in the
United States at
Firestone in
Akron, Ohio, two strokes ahead of runner-up
Bubba Watson.
PGA Tour Lowry accepted PGA Tour membership for the
2015–16 season. At the
2016 U.S. Open at
Oakmont Country Club near
Pittsburgh, Lowry shot 65 (−5) in the third round for 203 (−7) and a four-stroke advantage over
Dustin Johnson and
Andrew Landry at the 54-hole stage. The 65 was Lowry's joint career best round at a major championship. Due to weather delays on Thursday, the third round was not completed until early on Sunday, and Lowry birdied two of his remaining four holes to extend his two stroke overnight lead to four. In the final round he was in contention for the title, within one shot of Dustin Johnson after 12 holes, before three consecutive bogeys on holes 14, 15 and 16 ended his chances. He finished the tournament tied for second place, with a final round score of 76. Lowry did not win on the
European Tour from 2016 to 2018 but was joint runner-up in the 2017
DP World Tour Championship, Dubai and runner-up in the 2018
Andalucía Valderrama Masters. Lowry started the 2018–19 season with partial status after finishing 140th in the FedEx Cup. In January 2019, Lowry won the
Abu Dhabi HSBC Championship by one shot over
Richard Sterne. He led by 3 strokes after three rounds but was two-over-par after 11 holes of his final round and dropped 4 shots behind Sterne. However he finished with 3 birdies in the final 7 holes, while Sterne had two bogeys, giving Lowry the victory. In July, Lowry moved into a share of the 36-hole lead at the
2019 Open Championship at
Royal Portrush, after successive opening rounds of 67. He was tied at eight under with
J. B. Holmes. Lowry then shot a 63 for a new course record to lead by four strokes at the end of the third round. He won the tournament by six shots ahead of
Tommy Fleetwood. Lowry held the Claret Jug for two years due to the
COVID-19 pandemic postponing the 2020 edition of the Open Championship. In September 2021, Lowry played on the European team in the
2021 Ryder Cup at
Whistling Straits in
Kohler, Wisconsin. The U.S. team won 19–9 and Lowry went 1–2–0 including a loss in his Sunday singles match against
Patrick Cantlay. In February 2022, Lowry finished runner-up at
The Honda Classic.
Sepp Straka birdied the final hole to finish one shot ahead of him. In April, Lowry held the lead during the final round of the
RBC Heritage, however a double-bogey on the back nine, saw him finish one shot short of the playoff between
Patrick Cantlay and
Jordan Spieth. In September, Lowry won the
BMW PGA Championship at the
Wentworth Club. He shot a final-round 65 after the event had been shortened to 54 holes. He beat
Rory McIlroy and
Jon Rahm (who shot a 62 in the final round) by one stroke for his sixth European Tour victory. In September 2023, Lowry played on the European team in the
2023 Ryder Cup at
Marco Simone Golf and Country Club in
Guidonia,
Rome,
Italy. The European team won 16.5–11.5 and Lowry went 1–1–1 including a half in his Sunday singles match against
Jordan Spieth. In the third round of the
2024 PGA Championship, Lowry shot a record-tying 62, only the fifth in men's major history. In September 2025, Lowry was part of the European team in the
2025 Ryder Cup at
Bethpage Black Course in
Long Island, New York. The European team won 15–13. Lowry birdied a six-and-a-half footer at the 18th hole in his singles match against
Russell Henley to win the half point that ensured that Europe would retain the trophy, which they went on to win. ==Personal life==