Isufi made his professional debut on 10 April 2010, went his first 14 fights unbeaten until he lost to fellow German Dennis Ronert, but in his first three fights, two of them were draws. On 29 December 2015 Isufi won the vacant
International Boxing Federation East/West Europe
Light heavyweight Title against Slavisa Simeunovic in
Regensburg,
Germany. Right after the first title on 7 May 2016, Isufi won the vacant
Pan Asian Boxing Association Light heavyweight Title against Giorgi Beroshvili with TKO in round 2 and defended that title again after three months on 20 August 2016 against Mikheil Khutsishvili in
Alanya,
Turkey. Isufi started to compete to
Super middleweight and on 8 July 2017 he won the vacant
World Boxing Organization Inter-Continental Title against David Zegarra with
Knockout in round 11. Isufi was able to defend the title twice, on 16 February 2018 against Rafael Sosa Pintos and on 21 July 2018 against Mohamed El Achi, both fights Isufi won with unanimous decision after 10 rounds. From December 2018 to May 2019, Isufi was listed as a number 1 contender in the world in WBO
Super middleweight. On 18 May 2019, Isufi made his first attempt at a world title, by challenging
Billy Joe Saunders for a vacant World Title in
Super middleweight who lost with
unanimous decision after 12 rounds. After winning the Interim German International (BDB) Light Heavyweight Title against Bosko Misic with TKO in round 3, Isufi fought
Tomasz Adamek for WBF Intercontinental Light Heavyweight Title on 18 July 2021 and won the fight with unanimous decision after 10 rounds. On 16 April 2022 Isufi won the vacant WBF World title when he out-scored Bulgarian Grigor Saruhanian after 12 rounds with unanimous decision. == Accomplishments ==