After graduating from law school, Colb worked as a
law clerk, first for Judge
Wilfred Feinberg of the
United States Court of Appeals for the Second Circuit, and later for
Supreme Court Justice
Harry Blackmun. In 1993, she joined the faculty of
Rutgers Law School, initially as an assistant professor; she later gained tenure and became the Judge
Frederick Lacey Scholar there. In 2008, she left Rutgers to join the faculty of Cornell, where she served as the
Charles Evans Hughes Scholar before being named the inaugural C.S. Wong Professor of Law in 2019. Colb co-authored
Beating Hearts: Abortion and Animal Rights with Michael C. Dorf in 2016. Colb advocated for ethical
veganism, commenting that there are no good reasons to kill animals for food as people can easily meet all of their nutritional needs on a plant-based diet. Colb argued that sentient fetuses have the right not the be harmed or killed but there is no moral concern to abort pre-sentient fetuses. ==Personal life and death==