This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an
E3 ligase and is involved in
ubiquitination and
proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of
Parkinson's disease, the regulation of the cellular response to
hypoxia and induction of
apoptosis.
Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. == Interactions ==