Excessive production Conditions that can cause saliva overproduction include: •
Gastroesophageal reflux disease, in such cases specifically called a
water brash (a loosely defined lay term), and is characterized by a sour fluid or almost tasteless saliva in the mouth •
Gastroparesis (main symptoms are nausea, vomiting, and reflux) •
Pregnancy •
Fluoride therapy • Excessive
starch intake • Anxiety (common sign of
separation anxiety in dogs) •
Pancreatitis •
Liver disease •
Serotonin syndrome •
Mouth ulcers •
Oral infections •
Sjögren syndrome (an early symptom in some patients) Medications that can cause overproduction of saliva include: •
aripiprazole •
clozapine •
pilocarpine •
ketamine •
potassium chlorate •
risperidone •
pyridostigmine Substances that can cause hypersalivation include: •
mercury •
copper •
organophosphates (
insecticide) •
arsenic •
nicotine •
thallium Decreased clearance Causes of decreased clearance of saliva include: • Infections such as
tonsillitis,
retropharyngeal and
peritonsillar abscesses,
epiglottitis and
mumps. • Problems with the jaw, e.g., fracture or dislocation • Radiation therapy • Neurologic disorders such as
Amyotrophic lateral sclerosis,
myasthenia gravis,
Parkinson's disease,
multiple system atrophy,
rabies, bulbar paralysis, bilateral
facial nerve palsy,
frontotemporal dementia, and hypoglossal nerve palsy ==Treatment==