Siege of Mytilene can refer to one of the following sieges of the town of Mytilene, on the Greek island of Lesbos:Siege of Mytilene by the Athenians during the Mytilenean revolt Siege of Mytilene by the Persians under Memnon of Rhodes during the campaign of Alexander the Great Siege of Mytilene, by the Roman Republic Siege of Mytilene (1462), by the Ottoman Empire Siege of Mytilene (1464)