In 2010, Sigma Pharmaceutical restructured and sold its generic drug manufacturing business to South Africa’s Aspen Pharmacare for AUD$804 million, ending an almost 100-year legacy in the manufacturing field for the company. The pharmaceuticals division included generic brands, over-the-counter medications, its Herron brand, ethical products, medical products and the manufacturing businesses. In March 2014, Sigma acquired the healthcare product wholesaler and distributor Central Healthcare Services in a deal worth $24.5 million. In September 2014, the company bought the Queensland-based Discount Drug Store (DDS) banner for $26.7 million. The DDS acquisition was set to add 120 pharmacies under that brand to the Sigma network. In 2017, partly in response to Australian Government changes pharmacists’ payments under the Pharmaceutical Benefits Scheme, Sigma diversified further, acquiring Medication Packaging Systems (MPS), Australia's largest provider of dose administration services to the aged care sector and community pharmacy patients. During the 2020
COVID-19 pandemic, Sigma announced that it had sold the land and buildings of its distribution centres in Queensland and New South Wales, under an agreement to lease the facilities back from the new owners for an initial term of 15 years. The following year, Sigma launched a bid for
Australian Pharmaceutical Industries, which owned a number of rival retail pharmacy brands including Priceline, Pharmacist Advice and Soul Pattinson Chemists. The proposed merger, valued at AUD$773.5 million, was however withdrawn on 5 October 2021, with Australian retail conglomerate
Wesfarmers, announcing its purchase of 19.3% of API’s shares of API two days later. On 11 February 2022, the ACCC announced that it will not oppose the proposed acquisition of API by Wesfarmers. In September 2022 Sigma announced that it planned to consolidate its retail brands and focus franchise growth under the Amcal and Discount Drug Store brands. On 13 February 2025, Sigma Healthcare merged with the Chemist Warehouse Group and have new shares trading on the ASX. == Financial performance ==