More than 1,000 high-technology companies established offices in the area during the five years preceding 1998. Some early successful businesses were
Advanced RISC Machines and
Cambridge Display Technology. Cambridge Ahead, the business and academic membership organisation dedicated to the long-term growth of the city and its region, reported in 2015–16, that growth of Cambridge companies was approximately 7% over one, three, and five-year durations. Global turnover of Cambridge companies increased by 7.6% to £35.7bn, up from £33bn the previous year, and global employment grew by 7.6% to 210,292. The number of companies headquartered within 20 miles of Cambridge grew from 22,017 to 24,580. Silicon Fen, the high-tech cluster surrounding the University of Cambridge, demonstrates strong university–industry collaboration, particularly in the Pharma/Biotech sector, which accounts for most joint patents and the highest technological collaboration strength. Patent analysis (1999–2021) shows that university spin-offs drive these partnerships. Further analysis reveals that smaller and older firms collaborate more closely with the university and engage more female inventors. Promoting inclusion and collaboration beyond Pharma/Biotech could enhance innovation and regional technological development. ==Area characteristics==