Moreno-Garcia began her career publishing in various fiction magazines and books, including
Exile Quarterly. She was a finalist for the 2011
Manchester Fiction Prize. Her first short story collection,
This Strange Way of Dying, was published in September 2013 by
Exile Editions. Her second collection,
Love and Other Potions, came out in 2014 from Innsmouth Free Press. Her debut novel,
Signal to Noise, was published in 2015 by
Solaris Books. She serves as publisher of Innsmouth Free Press, an imprint devoted to weird fiction. With Paula R. Stiles, she co-edited the books
Historical Lovecraft (2011),
Future Lovecraft (2012),
Sword and Mythos (2014), and
She Walks in Shadows (2015). With Orrin Grey, she co-edited
Fungi (2013), a collection of "fungal fiction". With
Lavie Tidhar, she edits
The Jewish Mexican Literary Review. In 2016, she won a
World Fantasy Award—Anthology for
She Walks in Shadows. As of October 2019, Moreno-Garcia is a book columnist for
The Washington Post. In February 2020, her book
Gods of Jade and Shadow was announced finalist for the 2019 Nebula Award for Best Novel. Moreno-Garcia's novel
Mexican Gothic was published in 2021 to acclaim and received multiple awards and nomination.
Mexican Gothic was selected for the 2023 edition of
Canada Reads, where it was championed by Tasnim Geedi. Moreno-Garcia's 2022 novel
The Daughter of Doctor Moreau was also announced as a 2023 nominee for the
Hugo Award for Best Novel. Moreno-Garcia's novel
Silver Nitrate was published in 2023. Moreno-Garcia's 10th novel,
The Seventh Veil of Salome, was published in August 2024.
Kirkus Reviews called the book a "rousing success", noting the 1950s historical drama's strong Golden-Age inspired dialogue and suspense.
The New York Times reviewer Lauren LeBlanc wrote of Moreno-Garcia's writing, "Books that skew more cinematic than conventionally literary are often dismissed as formulaic, but in Moreno-Garcia’s skillful hands, you’ll find the satisfaction of richly drawn characters, saturated settings and deftly constructed plot twists. Inhaling her backlist has been the unexpected delight of my summer. No matter the genre — gothic, horror, noir — she’ll embody its essence with a verve all her own." ==Adaptations==