Moro began his climbing activity on the
Grigne near his home city. His father was his first mentor, and later Alberto Cosonni and Bruno Tassi. At that time he was primarily involved in rock climbing, an activity he has never given up. In 1992 he participated in his first Himalayan expedition, to
Mount Everest. One year later Moro climbed
Aconcagua in winter. He made expeditions to other mountains in the 1990s, including
Cerro Mirador in winter and
Makalu in 1993;
Shishapangma and
Lhotse in 1994,
Kangchenjunga in 1995. In 1996 Moro climbed the west wall of
Fitz Roy ( in
Patagonia) in 25 hours from the base to the summit and back to the base. In the same year, he climbed Shishapangma South () without oxygen in 27 hours using skis in the descent from . In 1997 he summited Lhotse. In Winter of 1997 he attempted the South face of
Annapurna. During this attempt, his climbing companions
Anatoli Boukreev and
Dimitri Sobolev died in an avalanche. He tried Everest again in 1998; summited four peaks
Pik Lenin (),
Peak Korzhenevskaya (),
Ismoil Somoni Peak (, formerly known as Pik Kommunizma), Pik
Khan Tengri () with young Kazakhstan guide
Denis Urubko; then summited Everest with him in 2000 In February 2016, Moro completed the first winter ascent of
Nanga Parbat with
Alex Txikon and
Ali Sadpara. In February 2018, he completed the first winter ascent of
Peak Pobeda, Sakha along with fellow Italian mountaineer
Tamara Lunger. ==Rescue missions==