On 18 October 1800, Sir John was married to Lady Amelia Grey at Bowden Church in Cheshire. Lady Amelia was the sixth daughter of
George Grey, Earl of Stamford and Warrington. The society marriage strengthened his entitlement. The couple had four sons and six daughters: •
Sir John Lister-Kaye, 2nd Baronet (1801–1871), who married Matilda Arbuthnot, sole heiress of George Arbuthnot, on 21 October 1824. •
George Lister-Kaye (1803–1871), a Captain of the
10th Dragoons. • Amelia Mary Lister Kaye (1803–1826), who married Falkiner Caleb Arthur Chute Sandes. • Arthur Lister Kaye (1805–1834), who became rector of Thornton, Yorkshire. • Sophia Lister Kaye (1807–1807) • Sophia Charlotte Lister Kaye (1809–1877), who married Rev. Henry Spencer Markham of
Clifton Rectory,
Nottinghamshire. • Louisa Lister Kaye (b. 1810) • Henrietta Emilia Lister Kaye (1811–1878) • Maria Lister Kaye (b. 1813) • Henry Lister Lister-Kaye (b. 1814) • Georgiana Lister Kaye (1815–1877), who married William Ford Hulton of
Hulton Park. When Sir John sold a portion of the Burton inheritance in 1827, it devolved on the Sykes family of Sledmere. Sir John died on 28 February 1827 and was succeeded in the baronetcy by his eldest son, Sir John. ==Arms==