The Wheeler-Denny-Cuffe, later Denny-Wheeler-Cuffe, later Wheeler-Cuffe Baronetcy, of Leyrath in the County of Kilkenny, was a title in the Baronetage of Ireland. It was created on 30 December 1800 for Jonah Wheeler-Denny-Cuffe. He later assumed the surname of Denny-Wheeler-Cuffe and served as Mayor of Kilkenny in 1823. The second and third Baronet used the surname Wheeler-Cuffe only. The title became extinct on the latter's death in 1934. The third Baronet was survived by his sister Pauline Florence Elizabeth. The baronetcy was the last created in the Baronetage of Ireland.