Armine married firstly, on 14 December 1619, Elizabeth Hicks, daughter of
Sir Michael Hicks of
Beverston Castle, Gloucestershire, and of Ruckholte, in Low Leyton, Essex. By her he had children:
William (1622–1658) who succeeded to the baronetcy, Theophilus (1623–1644) who became a parliamentary colonel in the civil wars and was killed at
Pontefract Castle,
Michael (1625–1688) who succeeded his brother to the baronetcy, Elizabeth (1621–1679), who married
Sir Thomas Style of
Wateringbury and Anne (1624–1671), who married
Sir Thomas Barnardiston of
Ketton, Suffolk. Armine married secondly, on 28 August 1628,
Mary Holcroft, widow of Thomas Holcroft of
Vale Royal Abbey (1557–1620) and daughter of Henry Talbot, son of the
Earl of Shrewsbury. She was a philanthropist who founded three hospitals, and also took an active interest in missionaries among Native Americans in England's colonies. By her, Sir William had one further child Talbot Armine (born 1630). ==References==