Sis Hopkins is a 1941 American comedy film directed by Joseph Santley and starring Judy Canova, Bob Crosby, Charles Butterworth, Jerry Colonna and Susan Hayward. It was produced and distributed by Republic Pictures, who made a number Canova films, and was released on April 12, 1941. Sis Hopkins was nominated for an Academy Award for Black-and-White Art Direction but that nomination was withdrawn by Republic Studios.