At the Battle of Issus (333 BCE), Darius's army was routed by
Alexander the Great, and the Persian king fled the field, leaving his extended family—including his mother; his wife,
Stateira I; his children; and many others—to the mercy of Alexander. He captured them but treated them with all dignity, where many others would have executed them out of hand. When Alexander and
Hephaestion went together to visit the captured Persian royal family, Sisygambis knelt to Hephaestion to plead for their lives, mistaking him for Alexander — Hephaestion was the taller, and both young men were similarly dressed. When she realized her mistake, she was acutely embarrassed, but Alexander reassured her with the words, "You were not mistaken, Mother; this man too is Alexander." At the
Battle of Gaugamela, Sisygambis and her family were kept within the baggage train behind Alexander's army. When the Persian army's Scythian cavalry broke through Alexander's forces to reach them, she allegedly refused to celebrate what appeared at first to be Persian victory. ==Under Alexander==