Main •
Natasha Calis as Nurse Hayley Roberts, a delivery nurse leaving a secret behind in Toronto. "mama bear" caretaker with a tough-as-nails attitude who is the soul of SkyMed. • Praneet Akilla as Jay "Chopper" Chopra, a pilot and engineer who aspires to be an astronaut and faces challenges in his personal relationships. • Aason ‘Ace’ Nadjiwon as Captain Austen Bodie (seasons 1–2; recurring, season 3), a hotshot pilot romantically involved with Hayley. • Mercedes Morris as Lexi Martine, an up-and-coming pilot who is often forced to choose between her convictions and her ambitions. • Thomas Elms as Captain Milosz Nowak, a pilot and bartender whose tough-love attitude wins him many colleagues but few friends. • Kheon Clarke as Tristan Green, an empathic, well-liked flight nurse. •
Braeden Clarke as Jeremy Wood (seasons 1–2; guest, season 3), Crystal's ex, North House's resident fixer and smuggler. •
Emilia McCarthy as Madison Van Camp (seasons 1–2; recurring, season 3), a local waitress and bartender involved with Bodie. • Rebecca Kwan as Emma Lin (season 1), an upbeat and professional ground nurse at North House First Nation, Crystal and Jeremy's home community. •
Patrick Kwok-Choon as Dr. Trevor Sung (season 1), an ER physician at the local hospital who is interested in Crystal both personally and professionally. •
Jeff Teravainen as Chief Pilot Pierce (season 1), SkyMed's commanding officer. • Sydney Kuhne as Stef (season 2–present), a paramedic and Lexi's girlfriend. •
Aaron Ashmore as Captain William "Wheezer" Heaseman (season 3–present; recurring, seasons 1–2), an experienced pilot, who prefers cargo flights over medivac flights. He is the den dad of the pilots and nurses, dispensing advice and grilled meat in equal measure. He also gets involved with flight nurse Hayley. •
Nicola Correia-Damude as Chief Nurse Marianne Fereira (season 3), a nurse who and PR expert who comes to head up the SkyMed nurses and runs them strictly.
Recurring • Ryan Ali as Reese • Matthew Kevin Anderson as Brad Maloney, a loading hand and pilot hopeful with questionable morals. • Ryan DeLong as Steve • Gino Anania as Devon, Emma's often too-serious fiancée. • Sharon Bajer as Denise, Bodie's mom • Laura Olafson as Darla • Karl Thordarson as Frank • Anthony Grant as TJ ==Production and development==