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SMC1B

Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene. SMC proteins engage in chromosome organization and can be broken into 3 groups based on function which are cohesins, condensins, and DNA repair. SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis. SMC1B protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human oocytes.

Function
SMC1B is essential for meiosis in which it has 3 main roles. SMC1B is known to be involved in the fusion of chromosomes during meiosis in both homologous and non-homologous chromosomes. Sister chromatid cohesion in meiosis is supplied by SMC1B. Additionally, in somatic cells SMC1B associates with SMC3 and RAD21 in a mitotic cohesin complex which had been thought to only include SMC1α. Depletion of SMC1B in somatic cells showed dysregulation of some gene expression. == Clinical Significance ==
Clinical Significance
Human Papillomavirus (HPV) Human Papillomavirus (HPV) is a DNA virus and the most prevalent sexually transmitted infection. HPV-16 and HPV-18 are responsible for most cases of cervical cancer from HPV. SMC1B has increased expression in HPV(+) cases. HPV recruits SMC1 along with a transcriptional factor, CTCF, to enable replication of the virus's genome. SMC1 is crucially important to the regulation of the virus life cycle. High expression of SMC1B can be associated with pancreatic cancers and ovarian cancer, while low expression increases the risk of cancer progression due to low genetic stability. == References ==
Source: Wikipedia ↗
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