Solomon Solis-Cohen was educated at public schools in Philadelphia. He received the Bachelor of Arts degree in 1872 and the Master of Arts degree in 1877 from
Philadelphia's Central High School. He taught Hebrew in the school of the Hebrew Education Society of Philadelphia for two years while studying medicine (1881–1883) and received his medical degree from the
Jefferson Medical College in 1883. Solis-Cohen taught in 1887–1902 at the Philadelphia Polyclinic and in 1890–1892 at Dartmouth College. He was a professor of clinical medicine at Jefferson Medical College from 1902 to 1927, when he retired as professor emeritus. He was a fellow of the American Association for the Advancement of Science and a trustee of the U.S. Pharmacopoeia Convention. His basic research in medicine was widely noted. He was a founder and trustee of the
Jewish Theological Seminary of America and a founder of the
Jewish Publication Society of America. He attended the
Third Zionist Congress at Basel in 1899 and was a member of the provisional executive of the
Zionist Organization of America for some time during WWI. He published a book of his poetry,
When love passed by, and other verses: including translations from Hebrew poets of the Middle Ages (1929), and a selection of his writings and addresses,
Judaism and Science, with other addresses and papers (1940). == Family ==